Q.1:Explain carbylamine recation with suitable example?
Ans:The carbylamine reaction, also known as Hofmann's isocyanide test is a chemical test for the detection of primary amines. In this reaction, the analyte is heated with alcoholic potassium hydroxide and chloroform. If a primary amine is present, the isocyanide (carbylamine) is formed which are foul smelling substances.
Q.2:Explaintheformationofpeptidebond?
Ans:A peptide bond is a chemical bond formed between two molecules when the carboxyl group of one molecule reacts with the amino group of the other molecule, releasing a molecule of water (H2O). This is a dehydration synthesis reaction (also known as a condensation reaction), and usually occurs between amino acids.
Explain carbylamine reaction with suitable example. Explain the formation of peptide bond?
Answer :
Explaining the carylamine reaction with example :-
The carbylamine reaction (also known as the Hoffmann isocyanide synthesis) is the synthesis of an isocyanide by the reaction of a primary amine, chloroform, and base.
The conversion involves the intermediacy of dichlorocarbene. Illustrative is the synthesis of tert-butyl isocyanide from tert-butylamine in the presence of catalytic amount of the phase transfer catalyst chloride.
Aliphatic or aromatic primary amines on heating with chloroform give foul (offensive) smelling products called isocyanides or carbylamines.
Now, Explaining the formation of peptide bond :-
A peptide bond is a chemical bond formed between two molecules when the carboxyl group of one molecule reacts with the amino group of the other molecule, releasing a molecule of water (H₂O).
This is a dehydration synthesis reaction (also known as a condensation reaction), and usually occurs between amino acids.
The resulting CO-NH bond is called a peptide bond, and the resulting molecule is an amide.
The four-atom functional group -C(=O)NH- is called an amide group or (in the context of proteins) a peptide group.
Polypeptides and proteins are chains of amino acids held together by peptide bonds, as is the backbone of PNA.
Answers & Comments
Q.1:Explain carbylamine recation with suitable example?
Ans:The carbylamine reaction, also known as Hofmann's isocyanide test is a chemical test for the detection of primary amines. In this reaction, the analyte is heated with alcoholic potassium hydroxide and chloroform. If a primary amine is present, the isocyanide (carbylamine) is formed which are foul smelling substances.
Q.2: Explain the formation of peptide bond?
Ans:A peptide bond is a chemical bond formed between two molecules when the carboxyl group of one molecule reacts with the amino group of the other molecule, releasing a molecule of water (H2O). This is a dehydration synthesis reaction (also known as a condensation reaction), and usually occurs between amino acids.
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Question :
Explain carbylamine reaction with suitable example. Explain the formation of peptide bond?
Answer :
Explaining the carylamine reaction with example :-
Me₃CNH₂ + CHCl₃ + 3 NaOH → Me₃CNC + 3 NaCl + 3 H₂O
Example :
Aliphatic or aromatic primary amines on heating with chloroform give foul (offensive) smelling products called isocyanides or carbylamines.
Now, Explaining the formation of peptide bond :-