Complete hydrolysis of DNA gives a pentose sugar, phosphoric acid and nitrogen containing heterocyclic compounds called bases. ( Adenine, Guanine, Cytosine and Thymine).
Especially from the perspective of catalyst understanding (and design)
, hydrolysis mechanisms must be addressed before reactivity data can be meaningfully considered. A considerable amount of data has been accumulated from physical organic chemistry studies on substitution reactions of
phosphodiesters and has been extensively reviewed (Westheimer 1968; Benkovic and Schray 1973; Knowles 1980; Thatcher and Kluger
1989; 1992; Gerlt 1993; Anslyn and Perreault 1997; Oivanen et al. 1998).
So only the most important points are recorded here.
This reaction is an associative process involving either intermediate or transition states of 5 coordinates. (These are the AN + DN and ANDN mechanisms
, respectively, according to IUPAC nomenclature.) For monoesters, the spontaneous unimolecular reaction (DN + AN) is a viable route (Fig. 1A, X = negative charge). . Even here the metaphosphate is believed not to be stable enough to be a sufficiently diffusible intermediate, and the substitution reaction
only occurs when the nucleophile is pre-bound to the phosphate
. (Jencks 1980, 1981). Therefore, even for monoesters, the current consensus is the
transition state with significant binding to both the nucleophile and the
leaving group in the transition states, especially the enzyme catalytic state.
pentose sugar :In chemistry, a pentose is a monosaccharide (monosaccharide) with five carbon atoms. The chemical formula for many pentoses is C.5H. 10 O.
The compounds obtained on complete hydrolysis of DNA is
Answers & Comments
Explanation:
Complete hydrolysis of DNA gives a pentose sugar, phosphoric acid and nitrogen containing heterocyclic compounds called bases. ( Adenine, Guanine, Cytosine and Thymine).
hydrolysis of DNA
Especially from the perspective of catalyst understanding (and design)
, hydrolysis mechanisms must be addressed before reactivity data can be meaningfully considered. A considerable amount of data has been accumulated from physical organic chemistry studies on substitution reactions of
phosphodiesters and has been extensively reviewed (Westheimer 1968; Benkovic and Schray 1973; Knowles 1980; Thatcher and Kluger
1989; 1992; Gerlt 1993; Anslyn and Perreault 1997; Oivanen et al. 1998).
So only the most important points are recorded here.
This reaction is an associative process involving either intermediate or transition states of 5 coordinates. (These are the AN + DN and ANDN mechanisms
, respectively, according to IUPAC nomenclature.) For monoesters, the spontaneous unimolecular reaction (DN + AN) is a viable route (Fig. 1A, X = negative charge). . Even here the metaphosphate is believed not to be stable enough to be a sufficiently diffusible intermediate, and the substitution reaction
only occurs when the nucleophile is pre-bound to the phosphate
. (Jencks 1980, 1981). Therefore, even for monoesters, the current consensus is the
transition state with significant binding to both the nucleophile and the
leaving group in the transition states, especially the enzyme catalytic state.
pentose sugar :In chemistry, a pentose is a monosaccharide (monosaccharide) with five carbon atoms. The chemical formula for many pentoses is C.5H. 10 O.
The compounds obtained on complete hydrolysis of DNA is
i) a pentose sugar
ii) two type of heterocyclic nitrogenous bases.
iii) phosphoric acid.
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