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Quinolines and indoles are both very common core motifs in drug molecules. Because they differ by just a single carbon in their ring frameworks, it would be useful to interconvert them during structure-activity relationship studies. However, aromatic stabilization in these compounds makes that process difficult. Woo et al. now report that narrow-wavelength irradiation of quinoline N-oxides in the near-ultraviolet range followed by acid treatment cleanly excises a ring carbon to produce an indole, avoiding secondary photoproducts that were previously observed using broadband light.
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Answer:
Algebra is the branch of mathematics that helps in the representation of problems or situations in the form of mathematical expressions. It involves variables like x, y, z, and mathematical operations like addition, subtraction, multiplication, and division to form a meaningful mathematical expression.
Answer:
To solve for speed or rate use the formula for speed, s = d/t which means speed equals distance divided by time. To solve for time use the formula for time, t = d/s which means time equals distance divided by speed.