• D. Organs make up organ system; tissues make up organs.

Explanation:

• Always remember the levels of the biological organizations. With that, you can easily identify what is larger, what is simpler, and what comprises which. In Thai case,we used this hierarchy to know the difference between organs and tissues.

Cells->Tissues->Organs->Organ Systems->Organism

• See? To understand this,you must know that the left side of a level is the one that comprises it. Like Cells to Tissues because cells make up tissues. Following the pattern,we would know that tissues make up organs and organs make up organ systems. And that explains my answer D. Their difference is the level that each of them makes up.
• Hope you find this answer and explanation helpful. Have a Scien-TERRIFIC Learning! Thank you!