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Ecological relationships can become disadvantageous in an ecosystem when they lead to a decline in the population of one or more species. This can occur, for example, when a predator's population becomes too large and begins to overconsume its prey, causing the prey population to decline. Another example is when a parasitic species becomes too abundant and harms its host population, disrupting the balance of the ecosystem. Additionally, when introduced species outcompete native species, ecological relationships can also become disadvantageous. Overall, when ecological relationships lead to imbalances in the ecosystem, it can be detrimental to the survival of certain species and the ecosystem as a whole.