Answer: Diterpenoid Euphorbol esters and Saponin-like detergents

Explanation: Animals, particularly domestic animals, have shown a very low incidence of toxic effects. Of those that do develop symptoms, gastrointestinal irritation (nausea, vomiting, diarrhea, hypersalivation) is the most common effect seen after ingestion of poinsettia.

Human

Most human exposures occur in children with only small amounts ingested or in contact with skin. In these situations, symptoms are infrequent. Those symptoms that do occur are due to irritation of the affected area. Poinsettia ingestions may produce vomiting and diarrhea. Dermal exposures to the sap of the plant may cause irritation. Most exposures result in either no clinical effects or only minor, self-limited symptoms.