Answer : Evolocumab[4] (trade name Repatha) is a monoclonal antibody medication designed for the treatment of hyperlipidemia.
EvolocumabMonoclonal antibodyTypeWhole antibodySourceHumanTargetPCSK9Clinical dataPronunciationEE-voh-lock-yoo-mabTrade namesRepathaOther namesAMG-145[1]AHFS/Drugs.comMonographLicense data
EU EMA: by INN
Pregnancy
category
AU: B1
Routes of
administrationSubcutaneousATC code
C10AX13 (WHO)
Legal statusLegal status
AU: S4 (Prescription only)[2]
US: ℞-only[3]
In general: ℞ (Prescription only)
IdentifiersCAS Number
1256937-27-5
ChemSpider
none
UNII
LKC0U3A8NJ
KEGG
D10557 
Chemical and physical dataFormulaC6242H9648N1668O1996S56Molar mass141790.89 g·mol−1
Evolocumab is a fully human monoclonal antibody that inhibits proprotein convertase subtilisin/kexin type 9 (PCSK9). PCSK9 is a protein that targets LDL receptors for degradation; its inhibition thereby enhances the liver's ability to remove LDL-C, often simplistically referred to as "bad" cholesterol, from the blood.[5][6]
Answers & Comments
Answer : Evolocumab[4] (trade name Repatha) is a monoclonal antibody medication designed for the treatment of hyperlipidemia.
EvolocumabMonoclonal antibodyTypeWhole antibodySourceHumanTargetPCSK9Clinical dataPronunciationEE-voh-lock-yoo-mabTrade namesRepathaOther namesAMG-145[1]AHFS/Drugs.comMonographLicense data
EU EMA: by INN
Pregnancy
category
AU: B1
Routes of
administrationSubcutaneousATC code
C10AX13 (WHO)
Legal statusLegal status
AU: S4 (Prescription only)[2]
US: ℞-only[3]
In general: ℞ (Prescription only)
IdentifiersCAS Number
1256937-27-5
ChemSpider
none
UNII
LKC0U3A8NJ
KEGG
D10557 
Chemical and physical dataFormulaC6242H9648N1668O1996S56Molar mass141790.89 g·mol−1
Evolocumab is a fully human monoclonal antibody that inhibits proprotein convertase subtilisin/kexin type 9 (PCSK9). PCSK9 is a protein that targets LDL receptors for degradation; its inhibition thereby enhances the liver's ability to remove LDL-C, often simplistically referred to as "bad" cholesterol, from the blood.[5][6]
Verified answer
Answer:
Each pre-filled cartridge with an automated mini-doser contains 420 mg of evolocumab in 3.5 mL of solution (120 mg/mL). Other ingredients:
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