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From older times, spices had played a vital role in the lifestyle of people from certain parts of the world. Herbs and spices have been used for generations by humans as food and to treat ailments. Bio-molecules in the plants play a crucial role in health maintenance and promotion. They have served numerous roles through history, including as coloring agents, flavoring agents, preservatives, food additives and medicine. The active photochemical derived from these spices have provided the molecular basis for these actions. There are several medicinal uses of spices in our daily life, many spices are used in kitchen and have certain medicinal activity like purgative, laxative, expectorant, carminative, diuretic etc. Since ancient time and till today spices are used for many purposes medicinally. Spices such as turmeric, fenugreek, mustard, ginger, onion and garlic have a wide variety of bio functions and their additive or synergistic actions are likely to protect the human body against a variety of insults. Traditionally spices, as part of the diets, have holistic effects on human health. Introduction In whole world, India is the most recognized country for the spices and traditional medicine; these are having a wide range of physiological and pharmacological properties. A spice is a dried seed, fruit, root, bark or flower of a plant or a herb used in small quantities for flavor, color or as a preservative. Moreover, for people of the world, spices stimulate appetite and create visual appeals to food. All types of spices were use from the ancient time in our kitchen for daily so they fulfill the body requirements on routine basis. Many of these substances are also used in traditional medicines. Globalization has made these spices easily available, and increasing their popularity. This chapter reviews the traditional uses of selected spices. In addition to making food taste good, culinary spices have been used as food preservatives and for their health-enhancing properties for centuries. Spices are functional foods; those can be demonstrated to have a beneficial effect on certain target functions in the body beyond basic nutritional requirements. The aim of this work is to review the nutritional and health benefits of some traditional spices mostly used in India