Vaccination efforts against COVID-19 are finally underway. In a global effort that is only as strong as its weakest link, support will be desperately needed to achieve what UNICEF has described as “one of the largest mass undertakings in human history.” But as we grapple with the logistical obstacles of vaccine delivery for low-income countries, the challenges go beyond the need for cold chain storage, airfreight distribution, and the supply of needles and vials.